Steps Follows

This example based on Ubuntu

Open the Grub configuration file

#vi /boot/grub/menu.lst

Add “nousb” at the end of the Kernel Line. Like the following

kernel /vmlinuz-2.6.18-128.1.1.el5 ro root=LABEL=/ console=tty0 console=ttyS1,19200n8 nousb

Secure GRUB with a strong Password !!!

#/sbin/shutdown -r now